Most cases in non-endemic countries are among gay, bisexual and other men who have sex with men. In the United States, the Centers for Disease Control and Prevention (CDC) reports 65 confirmed monkeypox cases as of June 13-and the number is growing daily. The World Health Organization (WHO) has confirmed 1,285 cases in more than two dozen non-endemic countries as well as 1,536 suspected cases in Africa this year. Health Security Agency (UKHSA) first reported the outbreak in early May, and the United Kingdom has had 470 confirmed cases as of June 12. It has mainly been seen in Central and West Africa, and this is the largest outbreak outside regions where the virus is endemic. The webinar, a collaboration between researchers, public health officials and community advocates, was co-organized by the Infectious Diseases Society of America, Fenway Health, GLMA, NASTAD and PrEP4All. On June 13, the HIV Medicine Association (HIVMA) hosted a monkeypox update for clinicians and the LGBT community.

While this outbreak has mainly affected gay and bisexual men so far, anyone can get monkeypox through close personal contact.

In May 2022, an outbreak of monkeypox began in Europe and North America.